The mere act of being born triggers development of the brain's sensory system, new research shows.
In a mouse study, the birthing process caused levels of a brain chemical called serotonin to drop, triggering the formation of the brain's sensory maps that organize input from vision, touch and other senses. The findings could help scientists understand healthy human brain development and mental illness, the researchers say.
"Our results clearly demonstrate that birth has active roles in brain formation and maturation," study leader Hiroshi Kawasaki of Kanazawa University in Japan said in a statement. [11 Surprising Facts About a Baby's Brain]
The brains of humans, mice and other mammals are equipped with maps for processing different types of sensory information. For example, the barrel cortex in rodents represents tactile information from the whiskers, and the layout of the neurons in that map mirrors the layout of whiskers on the animal's face.
Previously, researchers found that the brain chemical serotonin, the target of many depression medications, also plays a role in the development of sensory maps. But serotonin's exact involvement was not well understood.
Now, Kawasaki and his team have found the birthing process in mice causes a dip in serotonin in their brains, which triggers new neural wiring in the barrel cortex and the lateral geniculate nucleus (LGN), a brain region involved in visual processing. The researchers ruled out several other possible causes of the barrel cortex formation, such as increased tactile input after birth, or the release of the pups from their mamas (rather than the actual birthing process).
When the researchers gave the pregnant mice drugs to induce an early birth or lower their serotonin levels, circuits in the barrel cortex and LGN in the resulting newborn mice formed faster. But when they gave the mice a drug that boosted serotonin signaling, those circuits didn't form.
The findings, detailed on Oct. 14 in the journal Developmental Cell, suggest that reducing serotonin levels is key to healthy sensory map development.
Mental disorders often involve serotonin, so abnormal births and the effects on serotonin signaling might increase the risk of psychiatric illness, the researchers say. Once scientists understand the full effects of serotonin during birth, they may be able to develop therapies to reduce the risk of these illnesses, Kawasaki said.
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