Breast cancer patients at risk from soy
Isoflavones found in soy mimic the estrogen produced in the body and may hinder results of the drug tamoxifen.
Mon, Apr 02, 2012 at 04:24 PM
Photo: ZUMA Press
WASHINGTON — Eating soy could pose risks to some women who begin consuming it as adults by making breast cancer tumors resistant to treatment, U.S. researchers said on April 2.
A study on lab rats showed that those who were fed a soy compound all their lives responded well to a popular breast cancer drug, tamoxifen, but those who began eating it as adults, and after they developed breast cancer, grew resistant.
The research suggests a possible reason why tamoxifen stops working and allows tumors to grow again in some women, said scientists from Georgetown University who presented their findings at a medical conference in Chicago.
"These results suggest that Western women who started soy intake as adults, should stop if diagnosed with breast cancer," said senior author Leena Hilakivi-Clarke, professor of oncology at Georgetown.
Soy contains isoflavones that mimic the estrogen produced in the body, only at lower levels, and is considered a healthy protein source found in foods like tofu, miso, soy beans and soy milk.
Its potential benefits against breast cancer are often linked to the lower rates of hormone receptor positive types of breast cancer seen in Asian women who live in parts of the world where soy consumption is common.
Since tamoxifen is typically given to breast cancer patients with estrogen receptor and/or progesterone receptor positive types of tumors, the finding suggests that late-life adoption of a soy diet may have rendered the drug impotent.
The study was presented at the American Association for Cancer Research (AACR) Annual Meeting.
Copyright 2012 AFP Global Edition