A fungus that causes a deadly brain infection has a curious mating strategy, in which it reproduces with clones of itself, a new study finds.

Most species that reproduce sexually produce offspring that are a genetic mix of two different parents. But the yeast Cryptococcus neoformans produces offspring "unisexually," from two identical parents. These offspring have additional copies of certain chromosomes, or threadlike structures that carry DNA, creating genetic diversity from scratch, study researchers say.

Sexual reproduction exists to increase the genetic diversity of a species, making it more adaptable to different environments. But sex comes at a price, requiring two individuals to spend energy and resources looking for a mate. [Microscopic Worlds Gallery: Fascinating Fungi]

"Normally, it takes two parents that are genetically different from each other, and the offspring are recombinants," or genetic combinations, said study researcher Joseph Heitman, a molecular biologist at Duke University in Durham, N.C. "But if there's no pre-existing genetic diversity to mix up, what would be the function of the unisexual cycle?"

C. neoformans has two sexes, known as "a" and "alpha." An "a" and "alpha" can reproduce sexually (with each other), but since the vast majority of individuals are the alpha type, they were thought to reproduce asexually (from one individual). Then, in 2005, Heitman and his colleagues found that two genetically identical alpha yeast could reproduce together — unisexually.

Yeast sexual pairings often result in offspring with multiple copies of a chromosome, known as aneuploidy. This condition is associated with several human disorders, particularly Down syndrome, which results from having an extra copy of chromosome 21. But in fungi, aneuploidy can confer advantages, such as resistance to anti-fungal treatment.

In the new study, Heitman and his colleagues found that C. neoformans clones produced offspring that had traits different from their parents', such as drug resistance or pigmentation. The majority of those offspring had extra copies of chromosomes.

Some of the yeast later lost the extra chromosomes and became identical to their parents, suggesting the extra copies were responsible for the diversity of traits seen in the baby yeasts.

The yeast was reaping the benefits of sexual reproduction without some of the costs associated with sex, the researchers reported today (Sept. 10) in the journal PLOS Biology.

"This study pulls a lot of the pieces together into one coherent story," said microbiologist Richard Bennett of Brown University in Providence, R.I., who was not involved with the research. His own team has found that another yeast, called Candida albicans, also reproduces unisexually and produces aneuploid offspring. Whereas scientists had theorized that aneuploidy might yield diverse offspring, Heitman's team put everything together, Bennett told LiveScience.

In humans, C. neoformans can cause a life-threatening infection of the membranes that surround the brain. Most people are exposed to the fungus, but the infection generally strikes people with weakened immune systems. The pathogen causes more than 600,000 deaths a year, and is responsible for a third of all AIDS-related deaths.

Understanding how the yeast reproduces could eventually lead to better anti-fungal treatments, Heitman said.

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This story was originally written for LiveScience and has been republished with permission here. Copyright 2013 LiveScience, a TechMediaNetwork company.