Major breakthrough in influenza vaccine research
New universal flu vaccine would use the body's naturally occurring immune cells to fight the virus, and it could even work for future deadly strains.
Mon, Sep 23, 2013 at 11:32 AM
The health world is abuzz with news of a development that could potentially protect us all from deadly flu strains in the future.
Influenza kills between 250,000 and half a million people annually, according to the World Health Organization. And major pandemics are capable of causing millions of deaths across the globe, much like the Spanish flu outbreak of 1918, which was responsible for an estimated 30 to 50 million deaths worldwide.
Existing vaccines for the flu are effective, but not perfect. They rely on antibodies to fight the infection, but they only target the surface characteristics, which doesn’t stop the virus from adapting and mutating — thus more devious strains develop, creating the need to constantly create and administer upgraded vaccines.
But now researchers have made a breakthrough, discovering a “blueprint” for a universal vaccine that could protect against all strains of seasonal influenza, and remarkably, even future viruses that are as yet unknown.
During the 2009 swine flu pandemic, scientists monitored the health condition of more than 300 students and staff at the Imperial College London. They discovered that people who were minimally affected by the flu had a stronger presence of CD8 T cells in their blood at the start of the pandemic; CD8 T cells are naturally occurring immune cells the body uses to fight viruses.
Professor Ajit Lalvani, from the National Heart and Lung Institute at Imperial College London, who led the study, said that a vaccine that made the body produce more of these cells had the potential to be “the holy grail” and could potentially offer a universal vaccine effective against all strains of flu.
“The immune system produces these CD8 T cells in response to usual seasonal flu,” Lalvani said. “Unlike antibodies, they target the core of the virus, which doesn’t change, even in new pandemic strains. The 2009 pandemic provided a unique natural experiment to test whether T cells could recognize, and protect us against, new strains that we haven’t encountered before and to which we lack antibodies,” reports The Independent.
“We already know how to stimulate the immune system to make CD8 T cells by vaccination. … Now that we know these T cells may protect, we can design a vaccine to prevent people getting symptoms and transmitting infection to others,” Lalvani added. “This could curb seasonal flu annually and protect people against future pandemics.”
The results were published in the journal Nature Medicine.
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