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Study endorses HPV testing for all women over 30
Most cases of infection with the sexually transmitted virus are cleared naturally by the immune system, but persistent infection with certain HPV strains can lead to cervical cancer.
Wed, Dec 14 2011 at 7:01 PM
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LONDON - New DNA tests looking for the virus responsible for most cases of cervical cancer make sense for all women aged 30 or over, since they can prevent more cases of cancer than smear tests alone, Dutch researchers said on Thursday.
Results of a five-year study involving 45,000 women provided the strongest evidence yet in favor of using human papillomavirus (HPV) testing, Chris Meijer and colleagues from the VU University Medical Centre in Amsterdam reported in The Lancet Oncology.
Most cases of infection with the sexually transmitted virus are cleared naturally by the immune system, but persistent infection with certain HPV strains can lead to cervical cancer.
In recent years, tests for these "high-risk" strains have been developed by companies including Roche and Qiagen.
The new tests are known to work well in detecting HPV, but the Dutch study is the first to show they are better than Pap smears alone over two screening rounds set five years apart.
The researchers, who looked at women aged 29 to 56, said use of HPV tests led to earlier detection of pre-cancerous lesions, allowing for treatment that improved protection against cancer.
Hormuzd Katki and Nicolas Wentzensen from the U.S. National Cancer Institute said the results reinforced earlier findings, and provided "overwhelming evidence" of the benefits of including HPV testing in cervical screening programs.
(Reporting by Ben Hirschler; Editing by David Hulmes)
Copyright 2011 Reuters US Online Report Health News

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Eliz52
Feb 04 2013 at 1:21 AM
Women should watch the Dutch and Finns, they have evidence based programs, focused on what's best "for women". (not vested interests) Excess is the norm in the States and Australia so beware, do your research and protect your healthy body. The Dutch will scrap population pap testing (they currently have a 7 pap test program, 5 yearly from 30 to 60) and will offer 5 hrHPV primary triage tests at ages 30,35,40,50 and 60 and only the roughly 5% who are HPV+ and at risk will be offered a 5 yearly pap
.... More
test. Most women are HPV- and cannot benefit from pap testing. The Dutch are also using a long overdue self test HPV device.
Population pap testing condemns most women to a lifetime of unnecessary pap testing with the high risk of false positives and potentially harmful over-treatment. Excessive and early pap testing greatly increases the risks for no additional benefit. Over-treatment can damage the cervix and lead to infertility, miscarriages, premature babies, c-sections etc
The Finns have a 7 pap test program as well, 5 yearly from 30 to 60, and it's been in place since the 1960s, so this is not new evidence. Over-screening has caused enormous harm and worry, most of it was avoidable with testing in responsible hands. The lack of respect for informed consent and even consent (medical coercion, testing is "required" to get the Pill etc) should be a scandal. All cancer screening is elective, it can never be "required" for anything. Yet women have been denied their legal right to make an informed decision about testing. Informed consent is our legal right. Women should demand real information, respect for informed consent, including the right to decline testing and for access to smarter testing. (HPV primary testing and self-testing) As a low risk woman my risk of cc was near zero, the risks were too high for me and I have always declined testing. HPV Today, Edition 24, sets out the new Dutch program.
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