Nov. 22 marks the 50th anniversary of John F. Kennedy's assassination. That death stunned the world and caused an outpouring of public grief unprecedented in modern United States history.

Some even say that the killing of the 35th president altered the course of history, and that the United States would not have become embroiled in the Vietnam War had he lived.

But JFK isn't the only leader to have died by another's hands. He joins a long list of leaders who were murdered for political reasons. From the stabbing of Julius Caesar to the shooting of Mahatma Gandhi, here are eight of the most famous assassinations in history. [Which U.S. Leaders Have Been Assassinated?]

Vincenzo Camuccini's painting

Vincenzo Camuccini's painting "The Death of Ceasar" (1798). (Image: Wikimedia Commons)

1. Roman tragedy

Et tu, Brute? Despite having lived more than 2,000 years ago, Julius Caesar remains one of the most famous leaders to have met a brutal end. The "dictator in perpetuity" of the Roman Empire died on the Ides of March in 44 B.C. Senators Brutus and Cassius led a gang of senators called the Liberators and stabbed the leader to death outside the Theater of Pompey. Their motive? They feared Caesar planned to do away with the Senate and create a dictatorship. Of course, once they got Caesar out of the way, they set up a tyrannical government themselves.

A photograph of Lincoln from February 1865, two months before he was assassinated.

A photograph of Lincoln from February 1865, two months before he was assassinated. (Photo: Wikipedia)

2. Honest Abe

Abraham Lincoln, hailed by many historians as America's greatest president, was at a high point in 1865 when he was murdered. He had ended slavery, preserved the Union through the Civil War, and was embarking on the long road to reconstruction. The president was attending a play at Ford's Theatre in Washington, D.C., when actor John Wilkes Booth slipped into the president's booth and shot him in the head on Good Friday, April 14, 1865. Booth then leapt onto the stage wielding a knife and said, "Sic semper tyrannis," or "thus always to tyrants," a famous line attributed to Brutus at Caesar's assassination. [Busted: 6 Civil War Myths]

Gandhi with Lord and Lady Mountbatten in 1947

Gandhi (center) with Lord and Lady Mountbatten in 1947. Lord Mountbatten served as the last British Viceroy of India and oversaw the transition of India to an independent country. (Photo: Wikipedia)

3. Nonviolent leader

Mohandas K. or "Mahatma" Gandhi led India's successful bid for independence from Great Britain from the 1920s to the 1940s. Instead of relying on a revolution, Gandhi used nonviolence to accomplish this feat. But on Jan. 30, 1948, Nathuram Godse, a Hindu nationalist who opposed Gandhi's nonviolent approach and perceived favoritism towards Muslims, fired three shots at the leader at the Birla House in New Delhi, killing him. Millions of people came to honor the leader in his funeral procession.

Martin Luther King Jr during a press conference in 1964

Martin Luther King Jr during a press conference in 1964. (Photo: Wikimedia Commons)

4. Civil rights giant

Martin Luther King Jr. was the superstar of the civil rights movement and, like Gandhi, relied on nonviolence and civil disobedience to push for desegregation, voting rights and other civil rights for African Americans. Despite King's steadfast commitment to nonviolence, his opponents, mostly Southern whites opposed to desegregation and enfranchisement for African-Americans, weren't so restrained. White supremacists orchestrated bombings, beatings and murders to maintain the status quo, and King eventually became one of the victims. He was shot on April 4, 1968, while standing on the balcony of the Lorraine Motel in Memphis, Tenn. Authorities convicted James Earl Ray, a racist petty criminal, for the assassination, but for decades, rumors have swirled that Ray was part of a government plot to kill King.

Robert F. Kennedy during a press conference in 1968

Robert F. Kennedy during a press conference in 1968. (Photo: Wikipedia)

5. Ill-fated family

The Kennedy family has been dogged by tragedy for many generations. On Nov. 22, 1963, a sniper shot and killed John F. Kennedy as he was traveling with a motorcade in Dealey Plaza in Dallas, Texas. The Warren Commission concluded that Lee Harvey Oswald, a former Marine who had defected to the Soviet Union but returned to the United States, acted alone and fired the shots from the sixth floor of a nearby book depository. Many believe the official story is wrong, and 50 years later, conspiracy theories continue to circulate. [Why JFK Conspiracy Theories Won't Die]

Five years later, on June 5, 1968, JFK's younger brother Robert F. Kennedy was assassinated while campaigning for the presidency. He had just won the California presidential primary and was leaving the ballroom of the Ambassador Hotel in Los Angeles, when Sirhan Sirhan, a Palestinian Christian, opened fire and killed the presidential hopeful because of his support for Israel.

John Lennon with his wife Yoko Ono in March 1971

John Lennon with his wife Yoko Ono in March 1971. (Photo: Evening Standard/Getty Images)

6. Music icon

Though most assassinations are political, some killings seem to have little political rationale. John Lennon, one of the world's most famous musicians and a former member of the Beatles, was entering his home at The Dakota in New York City when he was shot and killed by Mark David Chapman on Dec. 8, 1980. At his trial, Chapman initially planned to plead insanity but later changed his plea to guilty, saying it was the will of God.

Soldiers arrest Gavrila Prinzip, assassin of the Archduke Franz Ferdinand in Sarajevo

Soldiers arrest Gavrila Prinzip follow his assassination of the Archduke Franz Ferdinand in Sarajevo. (Photo: Wikimedia Commons)

7. Young duke

Archduke Franz Ferdinand, heir to the throne of the Austro-Hungarian Empire, wasn't exactly a well-loved personality, and was described by historians as suspicious, hysterical and unpopular. Still, he did accomplish one stunning feat: His death inadvertently launched the First World War. The duke was shot on June 28, 1914, in Sarajevo, Bosnia, by Gavrilo Princip, a member of a Yugoslav independence movement known as Young Bosnia and an assassin for The Black Hand, a secret society formed by members of the Serbian Army. Austria-Hungary believed the Serbian military was involved in the plot and issued an ultimatum, then invaded Serbia when part of the ultimatum was rejected. A tangle of political alliances then swept all the major world powers into the war, leading to millions of deaths.

Malcolm X in March 1964

Malcolm X before a press conference in March 1964. (Photo: Wikimedia Commons)

8. Black power

Malcolm X was one of the most galvanizing political figures of the 1950s and 1960s. He grew up an orphan and spent time in prison, where he became a member of the Nation of Islam. He soon began promoting its ideas. Unlike Dr. King, Malcolm X rejected non-violence as a strategy and advocated for black separatism, saying African-Americans couldn't succeed in a racist society dominated by whites.  But when Malcolm X fell out with the Nation of Islam leadership, he became a marked man. Three Nation of Islam members shot and killed the leader on Feb. 21, 1965, while he was giving a speech at the Audubon Ballroom in New York City.

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