There is actually not any significant evidence that the Solanum spp., including tomatoes, potatoes, and peppers - have toxic foliage. They may not taste amazing, but comparing them to nightshade is a mistake, quite likely furthered by Europeans' first reactions to the Solanums. Because they looked like nightshade, they assumed that they were poisonous - including the fruits and roots - which we eat all the time. That's not to suggest you rush into the garden and start noshing on the tomato.... More