Charlotte Brosnan, the daughter of actor Pierce Brosnan, has passed away after a three-year battle with ovarian cancer. 

“On June 28 my darling daughter Charlotte Emily passed on to eternal life, having succumbed to ovarian cancer," he said in a statement.

“She was surrounded by her husband Alex, children Isabella and Lucas and brothers Christopher and Sean.

“Charlotte fought her cancer with grace and humanity, courage and dignity. Our hearts are heavy with the loss of our beautiful dear girl.

“We pray for her and that the cure for this wretched disease will be close at hand soon. We thank everyone for their heartfelt condolences.”

Charlotte's mother, Cassandra Harris, and also Brosnan's first wife, died from ovarian cancer in 1991 at age 43. Harris's mother also perished from the disease. 

Such a tragic history brings to mind the recent op-ed by Angelina Jolie detailing her own efforts to avoid her family's susceptibility to breast and ovarian cancer. The actress revealed that testing confirmed she carried the faulty BRCA1 gene - which may have contributed to the early deaths of her grandmother, mother, and most recently, her aunt.

In an interview with the Daily Mail in March, Brosnan talked about losing Harris to cancer when discussing his film "Love Is All You Need." The film is about a widower who falls in love with a woman recovering from breast cancer. 

"I went through it all, very publicly. Such things draw a mark across your heart and it’s always a part of your life. To watch someone you love have their life eaten away – bit by bit, by this insidious and horrid disease – becomes an indelible part of your psyche," he said. "It certainly did for me and, of course, when I received this script, the challenge of playing this part was not lost on me."

Related on MNN: What is the BRCA1 gene?

Michael d'Estries ( @michaeldestries ) covers science, technology, art, and the beautiful, unusual corners of our incredible world.

Pierce Brosnan's daughter dies of ovarian cancer at 41
Charlotte Brosnan battled the disease for three years before passing away on June 28th.