For a new series of PSAs drawing attention to the plight of children in Africa suffering from malaria, the organization Malaria No More decided to go for the heart and the funny bone.

Celebrities like Orlando Bloom, John Mayer, Ted Danson, Elizabeth Banks, Josh Groban, Jeremy Piven and others are the faces behind the "Comedy Fights Malaria" (CFM) campaign. "[The initiative] is a fresh, different, and truly funny way to get people thinking about a serious opportunity to save lives," said B.J. Novak, co-executive producer of "The Office" and a creative force behind CFM.

While the disease was eradicated in the United States more than 60 years ago, it continues to claim the lives of more that 850,000 people every year — most of them children under the age of 5 in Africa.

"The great thing about using comedy is that we're able to entertain and surprise people while showing them how they can contribute to the fight against malaria," said Elizabeth Banks. "Since malaria is not a problem in the U.S., it's easy to forget about it. But by keeping malaria in the spotlight, we can make malaria no more."

Using tools like mosquito nets, safe indoor spraying and effective medicines, the organization has a goal of wiping out the disease in Africa by 2015.

Check out one of the humorous PSAs below — and visit the campaign's Facebook page for more videos and helpful information on how to donate.

Michael d'Estries ( @michaeldestries ) covers science, technology, art, and the beautiful, unusual corners of our incredible world.