Supai Village, Arizona
Supai, Arizona, located within Havasu Canyon, is the capital of the Havasupai Indian Reservation with a population of just over 200. There are no roads — the only way in or out of the village is by helicopter or hiking an 8-mile trail (you can also ride a mule) — and the U.S. Department of Agriculture has called it the most remote community in the Lower 48.
While the village is located near the Grand Canyon, the Havasupai Tribe administers the land, which lies outside the boundary and jurisdiction of Grand Canyon National Park, according to the National Park Service. Residents still get mail delivered via mule (there are no automobiles). Visitors are warned that the canyon is subject to flash floods from the nearby Colorado River and the tourist-attracting Havasu Falls and may be closed at any time.
Havasu Canyon holds another similar honor: It's one of the quietest places on Earth.